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Shining a light on photolyases

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Photolyases are enzymes involved in the repair of ultraviolet light–induced DNA damage when activated by light absorption. The generation of photolyase transgenic mice now suggests that an improved understanding of the mechanisms of skin damage and carcinogenesis induced by sunlight is in the offing.

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Figure 1: Schematic CPD-photolyase phylogenetic tree.

BOB CRIMI

Figure 2: Schematic representation of the approaches used to distinguish the consequences of UV-induced lesions with photolyases.

BOB CRIMI

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  1. Depto. de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil

    Carlos F.M. Menck

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  1. Carlos F.M. Menck
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Menck, C. Shining a light on photolyases. Nat Genet 32, 338–339 (2002). https://doi.org/10.1038/ng1102-338

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