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PRDM9 marks the spot

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A new study demonstrates that PRDM9 variation in humans leads to profound differences in the activity of hotspots for both allelic recombination and genomic instability. Although PRDM9 is found to play a role in many more human hotspots than previously suspected, the search remains for additional, undetermined factors involved in defining hotspot locations and intensities.

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Figure 1: View of how PRDM9 variation influences both allelic and nonallelic recombination at individual hotspots.

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Authors and Affiliations

  1. Gil McVean and Simon Myers are at The Wellcome Trust Centre for Human Genetics, Oxford, UK.,

    Gil McVean & Simon Myers

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  1. Gil McVean
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  2. Simon Myers
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Correspondence to Gil McVean.

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The authors declare no competing financial interests.

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McVean, G., Myers, S. PRDM9 marks the spot. Nat Genet 42, 821–822 (2010). https://doi.org/10.1038/ng1010-821

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