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GWAS identifies a common breast cancer risk allele among BRCA1 carriers

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A genome-wide association study conducted among women with deleterious BRCA1 mutations has identified a common allele associated with breast cancer risk in BRCA1 carriers and estrogen receptor–negative breast cancer in the general population. This suggests that genetic association studies focused on particular subtypes may provide further insight into complex diseases.

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Figure 1: Oversampling a specific disease subtype can greatly increase power in GWAS.

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Authors and Affiliations

  1. Peter Kraft is at the Harvard School of Public Health, Boston, Massachusetts, USA.,

    Peter Kraft

  2. Christopher A. Haiman is at the Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.,

    Christopher A Haiman

Authors
  1. Peter Kraft
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  2. Christopher A Haiman
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Corresponding author

Correspondence to Peter Kraft.

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The authors declare no competing financial interests.

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Kraft, P., Haiman, C. GWAS identifies a common breast cancer risk allele among BRCA1 carriers. Nat Genet 42, 819–820 (2010). https://doi.org/10.1038/ng1010-819

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