Two genome-wide association studies together report three new susceptibility loci for late-onset Alzheimer’s disease. CLU, PICALM and CR1 may be involved in amyloid-β clearance from the brain.
References
Ferri, C.P. et al. Lancet 366, 2112–2117 (2005).
Blennow, K., de Leon, M.J. & Zetterberg, H. Lancet 368, 387–403 (2006).
Lambert, J.-C. et al. Nat. Genet. 41, 1094–1099 (2009).
Harold, D. et al. Nat. Genet. 41, 1088–1093 (2009).
Goate, A. et al. Nature 349, 704–706 (1991).
Sherrington, R. et al. Nature 375, 754–760 (1995).
Levy-Lahad, E. et al. Science 269, 973–977 (1995).
Corder, E.H. et al. Science 261, 921–923 (1993).
Corder, E.H. et al. Nat. Genet. 7, 180–184 (1994).
Waring, S.C. & Rosenberg, R. Arch. Neurol. 65, 329–334 (2008).
Ashford, J.W. & Mortimer, J.A. J. Alzheimers Dis. 4, 169–177 (2002).
Carrasquillo, M.M. et al. Nat. Genet. 41, 192–198 (2009).
Laurén, J. et al. Nature 457, 1128–1132 (2009).
Nikolaev, A. et al. Nature 457, 981–989 (2009).
Wyss-Coray, T. et al. Proc. Natl. Acad. Sci. USA 99, 10837–10842 (2002).
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van Es, M., van den Berg, L. Alzheimer’s disease beyond APOE. Nat Genet 41, 1047–1048 (2009). https://doi.org/10.1038/ng1009-1047
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DOI: https://doi.org/10.1038/ng1009-1047
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