Cancer metastasis has historically been viewed in the context of the mutational spectra arising during development of the primary cancer. The identification of a new modifier of cancer metastasis efficiency in mice provides experimental support for a predisposition model in which metastatic potential is viewed as a heritable trait influenced by host genetic polymorphisms.
This is a preview of subscription content, log in via an institution to check access.
References
Nowell, P.C. Science 194, 23–28 (1976).
Fidler, I.J. & Kripke, M.L. Science 197, 893–895 (1977).
Ramaswamy, S., Ross, K.N., Lander, E.S. & Golub, T.R. Nat. Genet. 33, 49–54 (2003).
Hunter, K.W. Cancer Lett. 200, 97–105 (2003).
Park, Y.-G. et al. Nat. Genet. 37, 1055–1062 (2005).
Pharoah, P.D.P. et al. Nat. Genet. 31, 33–36 (2002).
Amundadottir, L.T. et al. PLOS Med. 1, 229–236 (2004).
Ruivenkamp, C.A. et al. Nat. Genet. 31, 295–300 (2002).
Ewart-Toland, A. et al. Nat. Genet. 34, 403–412 (2003).
Kifsted, T. et al. Int. J. Cancer 12, 640–644 (1998).
Minn, A.J. et al. J. Clin. Invest. 115, 44–55, 2005.
Qiu, T.H. et al. Cancer Res. 64, 5973–5981 (2004).
Haigis, K.M. et al. Proc. Natl. Acad. Sci. USA 101, 9769–9773 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Threadgill, D. Metastatic potential as a heritable trait. Nat Genet 37, 1026–1027 (2005). https://doi.org/10.1038/ng1005-1026
Issue Date:
DOI: https://doi.org/10.1038/ng1005-1026
- Springer Nature America, Inc.