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FANCL, as in ligase

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Biochemical purification has identified a new component of the Fanconi anemia complex. The protein has ubiquitin ligase activity and may be the long-sought enzyme responsible for monoubiquitination of FANCD2.

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Figure 1: Model of Fanconi anemia pathway.

Katie Ris

References

  1. Auerbach, A.D., Buchwald, M. & Joenje, H. Fanconi Anemia. in The Metabolic and Molecular Basis of Inherited Disease (eds. Scriver, C.R., Beaudet, A.L., Sly, W.S. & Valle, D.) 753–783 (McGraw-Hill, New York, 2001).

    Google Scholar 

  2. D'Andrea, A.D. & Grompe, M. Nat. Rev. Cancer 3, 23–34 (2003).

    Article  CAS  Google Scholar 

  3. Garcia-Higuera, I. et al. Mol. Cell 7, 249–262 (2001).

    Article  CAS  Google Scholar 

  4. Howlett, N.G. et al. Science 297, 606–609 (2002).

    Article  CAS  Google Scholar 

  5. Meetei, A.R. et al. Nat. Genet. 35, 165–170 (2003).

    Article  CAS  Google Scholar 

  6. Fanconi, G. Semin. Hematol. 4, 233–240 (1967).

    CAS  PubMed  Google Scholar 

  7. Yamamoto, K. et al. Mol. Cell. Biol. 23, 5421–5230 (2003).

    Article  CAS  Google Scholar 

  8. Garcia-Higuera, I., Kuang, Y., Naf, D., Wasik, J. & D'Andrea, A.D. Mol. Cell. Biol. 19, 4866–4873 (1999).

    Article  CAS  Google Scholar 

  9. Taniguchi, T. et al. Blood 100, 2414–2420 (2002).

    Article  CAS  Google Scholar 

  10. Vandenberg, C.J. et al. Mol. Cell 12, 247–254 (2003).

    Article  CAS  Google Scholar 

  11. Meetei, A.R. et al. Mol. Cell. Biol. 23, 3417–3426 (2003).

    Article  CAS  Google Scholar 

  12. Coscoy, L. & Ganem, D. Trends Cell Biol. 13, 7–12 (2003).

    Article  CAS  Google Scholar 

  13. Bruun, D. et al. DNA Repair advance online publication, 18 September 2003 (doi:10.1016/51568-7864 (03) 00112-5.

  14. van der Heijden, M.S., Yeo, C.J., Hruban, R.H. & Kern, S.E. Cancer Res. 63, 2585–2588 (2003).

    CAS  PubMed  Google Scholar 

  15. Taniguchi, T. et al. Nat. Med. 9, 568–574 (2003).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Oregon Health & Sciences University, Molecular and Medical Genetics, 3181 SW Sam Jackson Pk Rd, Portland, 97239, Oregon, USA

    Markus Grompe

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  1. Markus Grompe
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Grompe, M. FANCL, as in ligase. Nat Genet 35, 113–114 (2003). https://doi.org/10.1038/ng1003-113

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