Excessive exposure to visible light damages the vertebrate retina. New work demonstrates that two different pathways, a bright-light pathway and a low-light dependent pathway, mediate light-induced retinal death. Although both pathways are initiated by excessive activation of the photopigment rhodopsin, they differ in that only the bright-light pathway is AP-1-dependent and only the low-light pathway is dependent on phototransduction.
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Jacobson, S., McInnes, R. Blinded by the light. Nat Genet 32, 215–216 (2002). https://doi.org/10.1038/ng1002-215
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DOI: https://doi.org/10.1038/ng1002-215
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