A detailed knowledge of patterns of linkage disequilibrium in human populations is widely seen as a prerequisite for effective population-based disease gene mapping. New data suggest that linkage disequilibrium is highly structured into discrete blocks of sequence separated by hot spots of recombination.
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Goldstein, D. Islands of linkage disequilibrium. Nat Genet 29, 109–111 (2001). https://doi.org/10.1038/ng1001-109
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DOI: https://doi.org/10.1038/ng1001-109
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