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A gene for familial hemiplegic migraine maps to chromosome 19

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Abstract

Familial hemiplegic migraine is an autosomal dominant disorder of unknown pathogenesis in which the migrainous attacks are marked by the occurrence of a transient hemiplegia during the aura. While investigating CADASIL, mapped previously to chromosome 19, we observed that some patients had recurrent attacks of migraine with aura. Although the clinical and neuroimaging features of familial hemiplegic migraine differ markedly from CADASIL, we hypothesized that the same gene could be involved in the pathogenesis of both conditions. We chose two large pedigrees for linkage analysis of familial hemiplegic migraine. A maximum lod score > 8 was found with two markers that are also strongly linked to CADASIL Multilocus linkage analysis suggested that the loci responsible for the two diseases reside within an interval of about 30 cM on chromosome 19.

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Authors and Affiliations

  1. Laboratoire de Pathologie de l'Immunité, Faculté de Médecine Necker, Enfants-Malades, 156 rue de Vaugirard, 75730, Paris, Cedex 15, France

    Anne Joutel, Hugues Chabriat, Argentino Nibbio, Jacqueline Maciazek, Bénédicte Meyer, Marie-Anne Bach & Elisabeth Tournier-Lasserve

  2. Service de Neurologie, Hopital St Antoine, Paris, France

    Anne Joutel, Marie-Germaine Bousser, Valérie Biousse & Hugues Chabriat

  3. Clinique Neurologique du C.H. et U, Montpellier-Nîmes, France

    Pierre Labauge

  4. Unité de Génétique Moléculaire Humaine (CNRS URA 1445) Institut Pasteur, Paris, France

    Jean Weissenbach

  5. Généthon, 91000, Evry, France

    Jean Weissenbach

  6. Unité INSERM U358, CEPH, Paris, France

    G. Mark Lathrop

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  1. Anne Joutel
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  2. Marie-Germaine Bousser
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  3. Valérie Biousse
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  4. Pierre Labauge
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  5. Hugues Chabriat
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  6. Argentino Nibbio
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  7. Jacqueline Maciazek
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  8. Bénédicte Meyer
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  9. Marie-Anne Bach
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  10. Jean Weissenbach
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  11. G. Mark Lathrop
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  12. Elisabeth Tournier-Lasserve
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Joutel, A., Bousser, MG., Biousse, V. et al. A gene for familial hemiplegic migraine maps to chromosome 19. Nat Genet 5, 40–45 (1993). https://doi.org/10.1038/ng0993-40

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  • DOI: https://doi.org/10.1038/ng0993-40

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