Although genome-wide analyses have identified somatic alterations contributing to the pathogenesis of pediatric acute lymphoblastic leukemia (ALL), few studies have identified germline variants conferring risk of this disease. Two reports now provide the first genome-wide glimpse into the role of inherited alleles in ALL pathogenesis.
This is a preview of subscription content, log in via an institution to check access.
References
Mullighan, C.G. et al. Nature 446, 758–764 (2007).
Papaemmanuil, E. et al. Nat. Genet. 41, 1006–1010 (2009).
Treviño, L.R. et al. Nat. Genet. 41, 1001–1005 (2009).
Hasle, H., Clemmensen, I.H. & Mikkelsen, M. Lancet 355, 165–169 (2000).
Morrell, D., Cromartie, E. & Swift, M. J. Natl. Cancer Inst. 77, 89–92 (1986).
Ford, A.M. et al. Nature 363, 358–360 (1993).
Lichtenstein, P. et al. N. Engl. J. Med. 343, 78–85 (2000).
Hemminki, K. & Jiang, Y. Leukemia 16, 297–298 (2002).
Mullighan, C.G. et al. Nature 453, 110–114 (2008).
Mullighan, C.G. et al. N. Engl. J. Med. 360, 470–480 (2009).
Laken, S.J. et al. Nat. Genet. 17, 79–83 (1997).
Campbell, P.J. Nat. Genet. 41, 385–386 (2009).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Levine, R. Inherited susceptibility to pediatric acute lymphoblastic leukemia. Nat Genet 41, 957–958 (2009). https://doi.org/10.1038/ng0909-957
Issue Date:
DOI: https://doi.org/10.1038/ng0909-957
- Springer Nature America, Inc.