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Hedgehog in Wnterland

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Hedgehog signaling has a key role in hair follicle development, as well as in induction of the most common cancer in individuals of European descent, basal cell carcinoma (BCC). A new study shows that BCCs strongly resemble embryonic hair follicles and that BCC induction requires active Wnt/β-catenin signaling.

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Figure 1: Comparison of signaling events in basal cell carcinoma cells and hair follicle buds.

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Authors and Affiliations

  1. Dennis Roop is Director of the Regenerative Medicine and Stem Cell Biology Program, University of Colorado, Aurora, Colorado 80045, USA.,

    Dennis Roop

  2. Rune Toftgård is in the Department of Biosciences and Nutrition, Karolinska Institute, Huddinge SE-141 57, Sweden. dennis.roop@uchsc.edu,

    Rune Toftgård

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  1. Dennis Roop
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  2. Rune Toftgård
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Roop, D., Toftgård, R. Hedgehog in Wnterland. Nat Genet 40, 1040–1041 (2008). https://doi.org/10.1038/ng0908-1040

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