Skip to main content
Log in

Chromosome instability leaves its mark

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

Genomic instability is a common feature of human cancer. A new study identifies a putative gene expression signature of chromosome instability in solid tumors, with implications for both understanding the underlying mechanisms and improving prediction of clinical outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1

Image courtesy of Charles Lee

References

  1. Hanahan, D. & Weinberg, R.A. Cell 100, 57–70 (2000).

    Article  CAS  Google Scholar 

  2. Lengauer, C., Kinzler, K.W. & Vogelstein, B. Nature 396, 643–649 (1998).

    Article  CAS  Google Scholar 

  3. Carter, S.L., Eklund, A.C., Kohane, I.S., Harris, L.N. & Szallasi, Z. Nat. Genet. 38, 1043–1048 (2006).

    Article  CAS  Google Scholar 

  4. Phillips, J.L. et al. Cancer Res. 61, 8143–8149 (2001).

    CAS  PubMed  Google Scholar 

  5. Pollack, J.R. et al. Proc. Natl. Acad. Sci. USA 99, 12963–12968 (2002).

    Article  CAS  Google Scholar 

  6. Frigola, J. et al. Nat. Genet. 38, 540–549 (2006).

    Article  CAS  Google Scholar 

  7. Whitfield, M.L., George, L.K., Grant, G.D. & Perou, C.M. Nat. Rev. Cancer 6, 99–106 (2006).

    Article  CAS  Google Scholar 

  8. Fridlyand, J. et al. BMC Cancer 6, 96 (2006).

    Article  Google Scholar 

  9. Giacomini, C.P. et al. Cancer Res. 65, 9200–9205 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pollack, J. Chromosome instability leaves its mark. Nat Genet 38, 973–974 (2006). https://doi.org/10.1038/ng0906-973

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0906-973

  • Springer Nature America, Inc.

Navigation