Skip to main content
SpringerLink
Log in

Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse

  • Correspondence
  • Published:

From Nature Genetics

View current issue Submit your manuscript

A Correspondence to this article was published on 01 September 2006

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: IREB2-deficient mice show largely normal locomotion and similar histological and ultrastructural brain morphologies as wild-type mice.

References

  1. Hentze, M.W., Muckenthaler, M.U. & Andrews, N.C. Cell 117, 285–297 (2004).

    Article  CAS  Google Scholar 

  2. LaVaute, T. et al. Nat. Genet. 27, 209–214 (2001).

    Article  CAS  Google Scholar 

  3. Galy, B., Ferring, D. & Hentze, M.W. Genesis 43, 181–188 (2005).

    Article  CAS  Google Scholar 

  4. Smith, S.R. et al. Ann. NY Acad. Sci. 1012, 65–83 (2004).

    Article  CAS  Google Scholar 

  5. Ohl, F., Holsboer, F. & Landgraf, R. Behav. Res. Methods Instrum. Comput. 33, 392–397 (2001).

    Article  CAS  Google Scholar 

  6. Brunk, U.T. & Terman, A. Free Radic. Biol. Med. 33, 611–619 (2002).

    Article  CAS  Google Scholar 

  7. Wahlsten, D. et al. J. Neurobiol. 54, 283–311 (2003).

    Article  Google Scholar 

  8. Olson, E.N., Arnold, H.H., Rigby, P.W. & Wold, B.J. Cell 85, 1–4 (1996).

    Article  CAS  Google Scholar 

  9. Bothe, G.W., Bolivar, V.J., Vedder, M.J. & Geistfeld, J.G. Genes Brain Behav. 3, 149–157 (2004).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank M. Hrabé de Angelis and the German Mouse Clinic for their work and the staff of the EMBL animal house and C. Schneider for technical assistance. This work was supported in part by the Bundesministerium für Bildung und Forschung/Nationales Genomforschungsnetz and Eumorphia (grant no. EU QLG2-CT-2002-00930), and by funds from the Gottfried-Wilhelm-Leibniz-Prize to M.W.H.

Author information

Authors and Affiliations

  1. European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg, 69117, Germany

    Bruno Galy, Dunja Ferring & Matthias W Hentze

  2. Institute of Developmental Genetics, GSF-National Research Center for Environment and Health, Ingolstädter Landstrasse 1, Neuherberg, 85764, Germany

    Sabine M Hölter & Wolfgang Wurst

  3. Institute of Experimental Genetics, GSF-National Research Center for Environment and Health, Ingolstädter Landstrasse 1, Neuherberg, 85764, Germany

    Thomas Klopstock & Lore Becker

  4. Department of Neurology, Ludwig-Maximilians-Universität, Marchioninistrasse 15, München, 81377, Germany

    Thomas Klopstock & Lore Becker

  5. Max-Planck-Institüt of Psychiatry, Kraepelinstrasse 2-10, München, 80804, Germany

    Wolfgang Wurst

  6. Abteilung Zelluläre und Molekulare Pathologie, Deutsches Krebsforschungszentrum Heidelberg, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Sylvia Kaden & Hermann-Josef Gröne

Authors
  1. Bruno Galy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sabine M Hölter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Thomas Klopstock
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dunja Ferring
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lore Becker
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sylvia Kaden
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Wolfgang Wurst
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hermann-Josef Gröne
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Matthias W Hentze
    View author publications

    You can also search for this author in PubMed Google Scholar

Supplementary information

Supplementary Fig. 1

IREB2-deficient mice display altered ferritin and TFR1 expression in the brain. (PDF 119 kb)

Supplementary Fig. 2

Assessment of balance and motor coordination in wild-type versus IREB2-deficient mice using the accelerating rotarod. (PDF 67 kb)

Supplementary Table. 1

Total non-heme iron content in the brain of IREB2-deficient mice versus wild-type mice. (PDF 42 kb)

Supplementary Table. 2

Phenotyping of wild-type versus IREB2-deficient mice using the modified hole board test. (PDF 126 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Galy, B., Hölter, S., Klopstock, T. et al. Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse. Nat Genet 38, 967–969 (2006). https://doi.org/10.1038/ng0906-967

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0906-967

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation