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Elucidating mouse transmission ratio distortion

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A proportion of wild mice carry a variant region of chromosome 17 that results in severe transmission ratio distortion in males. The genetic basis of this distortion has long been enigmatic, but a recent study begins to disentangle it.

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Figure 1: Structure of the t complex and its proposed action on sperm function.

References

  1. Bauer, H., Willert, J., Koschorz, B. & Herrmann, B.G. Nat. Genet. 37, 969–973 (2005).

    Article  CAS  Google Scholar 

  2. Lyon, M.F. Ann. Rev. Genet. 37, 393–408 (2003).

    Article  CAS  Google Scholar 

  3. Olds-Clarke, P. Rev. Reprod. 2, 157–164 (1997).

    Article  CAS  Google Scholar 

  4. Herrmann, B.G., Koschorz, B., Wertz, K., McLaughlin, K.J. & Kispert, A. Nature 402, 141–146 (1999).

    Article  CAS  Google Scholar 

  5. Lyon, M.F. Genet. Res. 59, 27–33 (1992).

    Article  CAS  Google Scholar 

  6. Lyon, M.F., Schimenti, J.C. & Evans, E.P. Genetics 155, 793–801 (2000).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Planchart, A., You, Y. & Schimenti, J.C. Genetics 155, 803–812 (2000).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Lyon, M.F. Cell 44, 357–363 (1986).

    Article  CAS  Google Scholar 

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Lyon, M. Elucidating mouse transmission ratio distortion. Nat Genet 37, 924–925 (2005). https://doi.org/10.1038/ng0905-924

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