A proportion of wild mice carry a variant region of chromosome 17 that results in severe transmission ratio distortion in males. The genetic basis of this distortion has long been enigmatic, but a recent study begins to disentangle it.
References
Bauer, H., Willert, J., Koschorz, B. & Herrmann, B.G. Nat. Genet. 37, 969–973 (2005).
Lyon, M.F. Ann. Rev. Genet. 37, 393–408 (2003).
Olds-Clarke, P. Rev. Reprod. 2, 157–164 (1997).
Herrmann, B.G., Koschorz, B., Wertz, K., McLaughlin, K.J. & Kispert, A. Nature 402, 141–146 (1999).
Lyon, M.F. Genet. Res. 59, 27–33 (1992).
Lyon, M.F., Schimenti, J.C. & Evans, E.P. Genetics 155, 793–801 (2000).
Planchart, A., You, Y. & Schimenti, J.C. Genetics 155, 803–812 (2000).
Lyon, M.F. Cell 44, 357–363 (1986).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lyon, M. Elucidating mouse transmission ratio distortion. Nat Genet 37, 924–925 (2005). https://doi.org/10.1038/ng0905-924
Issue Date:
DOI: https://doi.org/10.1038/ng0905-924
- Springer Nature America, Inc.
This article is cited by
-
Genetically enhanced asynapsis of autosomal chromatin promotes transcriptional dysregulation and meiotic failure
Chromosoma (2012)
-
Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross
BMC Genetics (2010)
-
Genetic strategies for dissecting mammalian and Drosophila voltage-dependent anion channel functions
Journal of Bioenergetics and Biomembranes (2008)
-
The dynamic of the t-haplotype in wild populations of the house mouse Mus musculus domesticus in Israel
Mammalian Genome (2007)