A new study reports that androgen signaling induces DNA double-strand breaks and TMPRSS2-ERG rearrangements through androgen receptor–mediated recruitment of topoisomerase 2B. These findings shed light on the generation of the most common fusion oncogene in human cancer.
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Bartek, J., Hamerlik, P. & Lukas, J. On the origin of prostate fusion oncogenes. Nat Genet 42, 647–648 (2010). https://doi.org/10.1038/ng0810-647
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DOI: https://doi.org/10.1038/ng0810-647
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