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Mapping the strand-specific transcriptome of fission yeast

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Pervasive genome-wide transcription is widespread in eukaryotic cells, but key features of the transcriptome have yet to be fully characterized. A new study using antibody-based detection of RNA-DNA duplexes on tiling arrays now reveals a complex, strand-specific transcriptional world in fission yeast.

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Figure 1: Three levels of resolution showing pervasive interleaved transcription.

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Authors and Affiliations

  1. Thomas R. Gingeras is at the Department of Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, USA. tom_gingeras@affymetrix.com,

    Thomas R Gingeras

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  1. Thomas R Gingeras
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Competing interests

The author is a consultant and former employee of Affymetrix, Inc.

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Gingeras, T. Mapping the strand-specific transcriptome of fission yeast. Nat Genet 40, 935–936 (2008). https://doi.org/10.1038/ng0808-935

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