Skip to main content
SpringerLink
Log in

Fungal pathogenicity and morphological switches

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

The virulence of Candida albicans, a major human fungal pathogen, has been considered dependent on the ability to transition between different morphologies. A new study reports a screen of C. albicans mutants that demonstrates that pathogenesis can be dissociated from morphological switching and in vitro growth rate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Various morphological forms of C. albicans.

References

  1. Noble, S., French, S. Kohn, L.A., Chen, V. & Johnson, A.D. Nat. Genet. 42, 590–598 (2010).

    Article  CAS  Google Scholar 

  2. Butler, G. et al. Nature 459, 657–662 (2009).

    Article  CAS  Google Scholar 

  3. Shea, J.E., Santangelo, J.D. & Feldman, R.G. Curr. Opin. Microbiol. 3, 451–458 (2000).

    Article  CAS  Google Scholar 

  4. Lay, J., et al. Infect Immun. 66, 5301–5306 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Csank, C. et al. Infect Immun. 66, 2713–2721 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Rocha, C.R. et al. Mol. Biol. Cell 12, 3631–3643 (2001).

    Article  CAS  Google Scholar 

  7. Arbour, M. et al. FEMS Yeast Res. 9, 1070–1077 (2009).

    Article  CAS  Google Scholar 

  8. Chen, X. et al. Mol. Microbiol. 51, 551–565 (2004).

    Article  CAS  Google Scholar 

  9. Lorenz, M.C., Bender, J.A. & Fink, G. Eukaryot. Cell 3, 1076–1087 (2004).

    Article  CAS  Google Scholar 

  10. Phan, Q.T., Belander, P.H. & Filler, S.G. Infect Immun. 68, 3485–3490 (2000).

    Article  CAS  Google Scholar 

  11. Nobile, C.J. & Mitchell, A.P. Cell Microbiol. 8, 1382–1391 (2005).

    Article  Google Scholar 

  12. Nobile, C.J., Nett, J.E., Andes, D.R. & Mitchell, A.P. Eukaryot. Cell 5, 1604–1610 (2006).

    Article  CAS  Google Scholar 

  13. Hisajima, T. et al. Med. Mycol. 46, 697–704 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. P. T. Magee is in the Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.,

    P T Magee

Authors
  1. P T Magee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P T Magee.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Magee, P. Fungal pathogenicity and morphological switches. Nat Genet 42, 560–561 (2010). https://doi.org/10.1038/ng0710-560

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0710-560

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation