Sequence conservation of noncoding DNA across species can indicate functional conservation. However, a new study demonstrates notable differences between human and mouse stem cell regulatory networks, suggesting caution in generalizing from sequence to functional conservation.
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Pennacchio, L., Visel, A. Limits of sequence and functional conservation. Nat Genet 42, 557–558 (2010). https://doi.org/10.1038/ng0710-557
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DOI: https://doi.org/10.1038/ng0710-557
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