Two genome-wide association studies for testicular cancer report associations at three new loci, including two candidate genes previously implicated in testicular development, KITLG (ligand for the receptor tyrosine kinase) and SPRY4 (sprouty 4). These studies are notable for the high effect sizes detected and the biological plausibility of the candidate genes.
References
Kanetsky, P.A. et al. Nat. Genet. 41, 811–815 (2009).
Rapley, E.A. et al. Nat. Genet. 41, 807–810 (2009).
Henderson, B.E. et al. in Urological Cancer (ed. Skinner, D.G.) 237–250 (1983).
Swerdlow, A.J. et al. Lancet 350, 1723–1728 (1997).
Hemminki, K. & Li, X. Br. J. Cancer 90, 1765–1770 (2004).
Runyan, C. et al. Development 133, 4861–4869 (2006).
Easton, D.F. & Eeles, R.A. Hum. Mol. Genet. 17, R109–R115 (2008).
Goldstein, D.B. N. Engl. J. Med. 360, 1696–1698 (2009).
Manolio, T. et al. J. Clin. Invest. 118, 1590–1605 (2008).
Kraft, P. et al. Nat. Rev. Genet. 10, 264–269 (2009).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chanock, S. High marks for GWAS. Nat Genet 41, 765–766 (2009). https://doi.org/10.1038/ng0709-765
Issue Date:
DOI: https://doi.org/10.1038/ng0709-765
- Springer Nature America, Inc.
This article is cited by
-
The genomic landscape of testicular germ cell tumours: from susceptibility to treatment
Nature Reviews Urology (2016)
-
Identification of four new susceptibility loci for testicular germ cell tumour
Nature Communications (2015)
-
Polygenic susceptibility to testicular cancer: implications for personalised health care
British Journal of Cancer (2015)