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Wnt signaling in focal dermal hypoplasia

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Wnt signaling regulates several aspects of development and tissue homeostasis. Two new studies in this issue uncover the underlying mechanism for focal dermal hypoplasia, a multiorgan developmental disorder, and underscore the important role of Wnt proteins in ectodermal-mesodermal communication.

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Figure 1: Examples of focal dermal hypoplasia (FDH) and relationship to the lines of Blaschko.

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Authors and Affiliations

  1. Amy S. Paller is in the Departments of Dermatology and Pediatrics, Northwestern University's Feinberg Medical School, Chicago, Illinois 60611-2997, USA. apaller@northwestern.edu,

    Amy S Paller

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  1. Amy S Paller
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The author declares no competing financial interests.

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Paller, A. Wnt signaling in focal dermal hypoplasia. Nat Genet 39, 820–821 (2007). https://doi.org/10.1038/ng0707-820

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