RNA-based silencing mechanisms suppress gene expression through the sequence-specific activity of small RNAs. New studies in plants now identify atypical RNA polymerases that promote and maintain transcriptional silencing.
References
Matzke, M.A. & Birchler, J.A. Nat. Rev. Genet. 6, 24–35 (2005).
Almeida, R. & Allshire, R.C. Trends Cell Biol. 15, 251–258 (2005).
Kawasaki, H. & Taira, K. Curr. Opin. Mol. Ther. 7, 125–131 (2005).
Tomari, Y. & Zamore, P.D. Genes Dev. 19, 517–529 (2005).
Bartel, D.P. Cell 116, 281–297 (2004).
Baulcombe, D. Nature 431, 356–363 (2004).
Kanno, T. et al. Nat. Genet. 37, 761–765 (2005).
Herr, A.J., Jensen, M.B., Dalmay, T. & Baulcombe, D.C. Science 308, 118–120 (2005).
Onodera, Y. et al. Cell 120, 613–622 (2005).
Kanno, T. et al. Curr. Biol. 14, 801–805 (2004).
Xie, Z. et al. PLoS Biol. 2, 642–652 (2004).
Lippman, Z. et al. Nature 430, 471–476 (2004).
Kakutani, T., Jeddeloh, J.A., Flowers, S.K., Munakata, K. & Richards, E.J. Proc. Natl. Acad. Sci. USA 93, 12406–12411 (1996).
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Vaucheret, H. RNA polymerase IV and transcriptional silencing. Nat Genet 37, 659–660 (2005). https://doi.org/10.1038/ng0705-659
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DOI: https://doi.org/10.1038/ng0705-659
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