The human Y chromosome is the first constitutively haploid metazoan chromosome to be sequenced. It has a unique genomic landscape with a complex evolutionary history that has endowed it with few genes but many nearly identical dispersed repeats that underlie the structural fluidity of this unusual chromosome.
References
Koopman, P., Gubbay, J., Vivian, N., Goodfellow, P. & Lovell-Badge, R. Nature 351, 117–121 (1991).
Skaletsky, H. et al. Nature 423, 825–837 (2003).
Ohno, S. Sex chromosomes and sex-linked genes (Springer, Berlin, 1967).
Lahn, B.T. & Page, D.C. Science 286, 964–967 (1999).
Glaser, B. et al. Mamm. Genome 9, 226–231 (1998).
Fisher, R.A. Biol. Rev. 6, 345–368 (1931).
Bailey, J.A. et al. Science 297, 1003–1007 (2002).
Guy, J. et al. Genome Res. 13, 159–172 (2003).
Samonte, R.V. & Eichler, E.E. Nat. Rev. Genet. 3, 65–72 (2002).
Zimmer, E.A., Martin, S.L., Beverley, S.M., Kan, Y.W. & Wilson, A.C. Proc. Natl. Acad. Sci. USA 77, 2158–2162 (1980).
Rozen, S. et al. Nature 423, 873–876 (2003).
Stankiewicz, P. & Lupski, J.R. Trends Genet. 18, 74–82 (2002).
Blanco, P. et al. J. Med. Genet. 37, 752–758 (2000).
Bosch, E. & Jobling, M.A. Hum. Mol. Genet. 12, 341–347 (2003).
Repping, S. et al. Mol. Hum. Reprod. 9, 183–188 (2003).
Rossiter, J.P. et al. Hum. Mol. Genet. 3, 1035–1039 (1994).
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Hurles, M., Jobling, M. A singular chromosome. Nat Genet 34, 246–247 (2003). https://doi.org/10.1038/ng0703-246
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DOI: https://doi.org/10.1038/ng0703-246
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