The identification of hundreds of thousands of clusters of transcriptional start sites, many located within internal exons of protein-coding genes, indicates that promoter sites are common and that transcriptional organization is complex. This transcriptional architecture implies that most genomic regions serve multiple functions.
References
International Human Genome Sequencing Consortium. Nature 431, 931–945 (2004).
ENCODE Project Consortium. Science 306, 636–640 (2004).
Bertone, P. et al. Science 306, 2242–2246 (2004).
Carninci, P. et al. Science 309, 1559–1563 (2005).
Kapranov, P. et al. Science 296, 916–919 (2002).
Carninci, P. et al. Nat. Genet. 38, 626–635 (2006).
Bernstein, B.E. et al. Cell 120, 169–181 (2005).
Cawley, S. et al. Cell 116, 499–509 (2004).
Cheng, J. et al. Science 308, 1149–1154 (2005).
Kim, T.H. et al. Nature 436, 876–880 (2005).
Trinklein, N.D. et al. Genome Res. 14, 62–66 (2004).
Akiva, P. et al. Genome Res. 16, 30–36 (2006).
Kapranov, P. et al. Genome Res. 15, 987–997 (2005).
Parra, G. et al. Genome Res. 16, 37–44 (2006).
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Gingeras, T. The multitasking genome. Nat Genet 38, 608–609 (2006). https://doi.org/10.1038/ng0606-608
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DOI: https://doi.org/10.1038/ng0606-608
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