Inversin is a component of a poorly understood cilia-based mechanism responsible for specifying the left-right axis during development and for maintaining normal kidney architecture throughout life. A new study now suggests that inversin might act as a flow-regulated molecular switch between canonical and noncanonical Wnt pathways, providing insights into the mechanisms underlying cilia-based signaling processes.
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Katie Ris
Katie Ris
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Germino, G. Linking cilia to Wnts. Nat Genet 37, 455–457 (2005). https://doi.org/10.1038/ng0505-455
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DOI: https://doi.org/10.1038/ng0505-455
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