Abstract
High resolution linkage maps have proven to be invaluable tools in genetic investigations. We have assembled a collection of genetic maps constructed from primary data collected from investigators performing genotyping using the Centre Etude Polymorphism Humain (CEPH) reference pedigree panel. These maps were constructed using a rigorous, semi–automated map construction algorithm that evaluates the integrity of the maps during construction. Two classes of maps were produced: a high confidence “skeletal” set composed of 544 PCR based markers, and a more highly annotated “framework” set containing maps of 1,123 markers. Genetic map locations within the framework maps are provided for an additional 1,758 loci without statistically unique interval assignments.
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References
Dausset, J. et al. Centre d Etude du Polymorphisme Humain (CEPH): Collaborative Genetic Mapping of the Human Genome. Genomics 6, 575–577 (1990).
White, R.L. et al. The CEPH consortium primary linkage map of human chromosome 10. Genomics 6, 393–412 (1990).
Dracopoli, N.C. et al. The CEPH consortium linkage map of human chromosome 1. Genomics 9, 686–700 (1991).
NIH/CEPH Collaborative Mapping Group. A comprehensive genetic linkage map of the human genome. Science 258, 67–86 (1992).
Weissenbach, J. et al. A second-generation linkage map of the human genome. Nature 359, 794–801 (1992).
Keats, B.J.B. Linkage chromosome mapping in man. (University Press of Hawaii, Honolulu, 1981).
Donis-Keller, H. et al. A genetic linkage map of the human genome. Cell 51, 319–337 (1987).
Buetow, K.H. Influence of aberrant observations on high resolution linkage analysis outcomes. Am. J. hum. Genet. 49, 985–994 (1991).
Morton, N.E. Sequential tests for the detectlon of linkage. Am. J. hum. Genet. 7, 277–318 (1955).
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Buetow, K., Weber, J., Ludwigsen, S. et al. Integrated human genome–wide maps constructed using the CEPH reference panel. Nat Genet 6, 391–393 (1994). https://doi.org/10.1038/ng0494-391
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DOI: https://doi.org/10.1038/ng0494-391
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