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BMP6 orchestrates iron metabolism

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The small liver peptide hepcidin is a major regulator of systemic iron homeostasis in mammals, adapting iron absorption to the body's demands. Two new studies now identify BMP6 as the key endogenous regulator of hepcidin.

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Figure 1: Control of iron homeostasis by hepcidin in mammals.

Kim Caesar

References

  1. Ganz, T. & Nemeth, E. Biochim. Biophys. Acta 1763, 690–699 (2006).

    Article  CAS  Google Scholar 

  2. Meynard, D. et al. Nat. Genet. 41, 478–481 (2009).

    Article  CAS  Google Scholar 

  3. Andriopoulos, B. Jr, et al. Nat. Genet. 41, 482–487 (2009).

    Article  CAS  Google Scholar 

  4. Nemeth, E. et al. Science 306, 2090–2093 (2004).

    Article  CAS  Google Scholar 

  5. Camaschella, C. Blood 106, 3710–3717 (2005).

    Article  CAS  Google Scholar 

  6. Roetto, A. et al. Nat. Genet. 33, 21–22 (2003).

    Article  CAS  Google Scholar 

  7. Papanikolaou, G. et al. Nat. Genet. 36, 77–82 (2004).

    Article  CAS  Google Scholar 

  8. Andrews, N.C. Blood 112, 219–230 (2008).

    Article  CAS  Google Scholar 

  9. Babitt, J.L. et al. Nat. Genet. 38, 531–539 (2006).

    Article  CAS  Google Scholar 

  10. Wang, R.H. et al. Cell Metab. 2, 399–409 (2005).

    Article  CAS  Google Scholar 

  11. Niederkofler, V. et al. J. Clin. Invest. 115, 2180–2186 (2005).

    Article  CAS  Google Scholar 

  12. Babitt, J.L. et al. J. Clin. Invest. 117, 1933–1939 (2007).

    Article  CAS  Google Scholar 

  13. Kautz, L. et al. Blood 112, 1503–1509 (2008).

    Article  CAS  Google Scholar 

  14. Solloway, M.J. et al. Dev. Genet. 22, 321–339 (1998).

    Article  CAS  Google Scholar 

  15. Winnier, G. et al. Genes Dev. 9, 2105–2116 (1995).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Division of Genetics and Cell Biology, Clara Camaschella is at the Università Vita-Salute & Istituto Scientifico San Raffaele, Milano, Italy. camaschella.clara@hsr.it,

    Clara Camaschella

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  1. Clara Camaschella
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Camaschella, C. BMP6 orchestrates iron metabolism. Nat Genet 41, 386–388 (2009). https://doi.org/10.1038/ng0409-386

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