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Processing the H3K36me3 signature

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The global patterning of histone lysine methylation has been scrutinized over the years in an effort to uncover unique features indicative of chromatin function. A study in Caenorhabditis elegans now shows that nucleosomes covering exons and introns on active genes are differentially marked by H3K36 trimethylation, suggesting a new mode of communication between chromatin and pre-mRNA processing.

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Figure 1: The U1 snRNP and SR splicing proteins are recruited to active genes in part via RNA polymerase II (RNAPII), and CHD1 assists in U2 snRNP recruitment.

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Authors and Affiliations

  1. Robert J. Sims III is at Constellation Pharmaceuticals, Cambridge, Massachusetts 02139, USA.,

    Robert J Sims III

  2. Danny Reinberg is at the Department of Biochemistry, New York University School of Medicine, New York 10016 USA. reinbd01@nyumc.org robert.sims@constellationpharma.com,

    Danny Reinberg

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  1. Robert J Sims III
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  2. Danny Reinberg
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Sims III, R., Reinberg, D. Processing the H3K36me3 signature. Nat Genet 41, 270–271 (2009). https://doi.org/10.1038/ng0309-270

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