The mechanism by which cytosine methylation stably represses transcription is of great interest. A new study provides evidence associating DNA methylation, MeCP2 and the SWI/SNF chromatin-remodeling factor, implicating local chromatin architecture in DNA methylation–dependent transcriptional repression.
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Wade, P. SWItching off methylated DNA. Nat Genet 37, 212–213 (2005). https://doi.org/10.1038/ng0305-212
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DOI: https://doi.org/10.1038/ng0305-212
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