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Deregulation of H3K27 methylation in cancer

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A new study now reports recurrent somatic mutation of EZH2, a histone methyltransferase that modifies H3K27, in diffuse large B-cell lymphoma (DLBCL). There is now evidence for both increased and decreased activity of enzymes controlling H3K27 methylation in cancer, suggesting that a precise balance of this methylation is critical for normal cell growth.

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Figure 1: Deregulation of H3K27 methylation in cancer.

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Authors and Affiliations

  1. Eva Martinez-Garcia and Jonathan D. Licht are in the Division of Hematology-Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.,

    Eva Martinez-Garcia & Jonathan D Licht

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  1. Eva Martinez-Garcia
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  2. Jonathan D Licht
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Correspondence to Jonathan D Licht.

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Martinez-Garcia, E., Licht, J. Deregulation of H3K27 methylation in cancer. Nat Genet 42, 100–101 (2010). https://doi.org/10.1038/ng0210-100

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