Skip to main content
SpringerLink
Log in

A treasure trove for lipoprotein biology

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

Plasma lipoprotein concentrations are associated with risk of coronary artery disease, a leading cause of mortality and morbidity worldwide. Three new genome-wide association studies of thousands of individuals now identify seven genes or loci contributing to lipid concentrations and confirm a number of previously reported associations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The primary pathways for the metabolism of human plasma lipoproteins are summarized (figure modified from that of a previous study15).

Katie Ris-Vicari

References

  1. Kathiresan, S. et al. Nat. Genet. 40, 189–197 (2008).

    Article  CAS  Google Scholar 

  2. Kooner, J.S. et al. Nat. Genet. 40, 149–151 (2008).

    Article  CAS  Google Scholar 

  3. Willer, C.J. et al. Nat Genet 40, 161–169 (2008).

    Article  CAS  Google Scholar 

  4. Shimamura, M. et al. Arterioscler. Thromb. Vasc. Biol. 27, 366–372 (2007).

    Article  CAS  Google Scholar 

  5. Skropeta, D. et al. J. Lipid Res. 48, 2047–2057 (2007).

    Article  CAS  Google Scholar 

  6. Beigneux, A.P. et al. Cell Metab. 5, 279–291 (2007).

    Article  CAS  Google Scholar 

  7. Vaisar, T. et al. J. Clin. Invest. 117, 746–756 (2007).

    Article  CAS  Google Scholar 

  8. Rader, D.J. J. Clin. Invest. 116, 3090–3100 (2006).

    Article  CAS  Google Scholar 

  9. Ansell, B.J., Fonarow, G.C. & Fogelman, A.M. Curr. Opin. Lipidol. 18, 427–434 (2007).

    Article  CAS  Google Scholar 

  10. Cohen, J.C., Boerwinkle, E., Mosley, T.H. Jr & Hobbs, H.H. N. Engl. J. Med. 354, 1264–1272 (2006).

    Article  CAS  Google Scholar 

  11. Wang, J. et al. Arterioscler. Thromb. Vasc. Biol. 27, 2450–2455 (2007).

    Article  CAS  Google Scholar 

  12. Goring, H.H. et al. Nat. Genet. 39, 1208–1216 (2007).

    Article  Google Scholar 

  13. Schadt, E.E. & Lum, P.Y. J. Lipid Res. 47, 2601–2613 (2006).

    Article  CAS  Google Scholar 

  14. Shah, S.H. et al. Ann. Hum. Genet. 70, 738–748 (2006).

    Article  CAS  Google Scholar 

  15. Lusis, A.J., Fogelman, A.M. & Fonarow, G.C. Circulation 110, 1868–1873 (2004).

    Article  Google Scholar 

Download references

Author information

Author notes

  1. Päivi Pajukanta is in the Department of Human Genetics, University of California, Los Angeles, California 90095, USA. jlusis@mednet.ucla.edu

Authors and Affiliations

  1. Aldons J. Lusis is in the Departments of Human Genetics, Medicine and Molecular Genetics, and the Molecular Biology Institute, University of California, Los Angeles, California 90095, USA.,

    Aldons J Lusis & Päivi Pajukanta

Authors
  1. Aldons J Lusis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Päivi Pajukanta
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lusis, A., Pajukanta, P. A treasure trove for lipoprotein biology. Nat Genet 40, 129–130 (2008). https://doi.org/10.1038/ng0208-129

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0208-129

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation