Two new studies show that the Fanconi anemia complementation group N results from biallelic mutations in PALB2, which encodes a recently identified interaction partner of the breast cancer susceptibility protein BRCA2. A third study shows that monoallelic PALB2 mutations are associated with breast cancer susceptibility, providing yet more links between Fanconi anemia, homologous recombination repair and cancer predisposition.
References
Lobitz, S. & Velleuer, E. Nat. Rev. Cancer 6, 893–898 (2006).
Niedernhofer, L.J., Lalai, A.S. & Hoeijmakers, J.H. Cell 123, 1191–1198 (2005).
Xia, B. et al. Nat. Genet. 39, 159–161 (2007).
Reid, S. et al. Nat. Genet. 39, 162–164 (2007).
Xia, B. et al. Mol. Cell 22, 719–729 (2006).
Rahman, N. et al. Nat. Genet. 39, 165–167 (2007).
Patel, K.J. et al. Mol. Cell 1, 347–357 (1998).
Howlett, N.G. et al. Science 297, 606–609 (2002).
Pellegrini, L. & Venkitaraman, A. Trends Biochem. Sci. 29, 310–316 (2004).
Seal, S. et al. Nat. Genet. 38, 1239–1241 (2006).
Alter, B.P., Rosenberg, P.S. & Brody, L.C. J. Med. Genet. 44, 1–9 (2007).
Niedzwiedz, W. et al. Mol. Cell 15, 607–620 (2004).
Yamamoto, K. et al. Mol. Cell. Biol. 25, 34–43 (2005).
Bridge, W.L., Vandenberg, C.J., Franklin, R.J. & Hiom, K. Nat. Genet. 37, 953–957 (2005).
Mosedale, G. et al. Nat. Struct. Mol. Biol. 12, 763–771 (2005).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Patel, K. Fanconi anemia and breast cancer susceptibility. Nat Genet 39, 142–143 (2007). https://doi.org/10.1038/ng0207-142
Issue Date:
DOI: https://doi.org/10.1038/ng0207-142
- Springer Nature America, Inc.
This article is cited by
-
The biological effects and clinical implications of BRCA mutations: where do we go from here?
European Journal of Human Genetics (2016)
-
Fanconi anemia and breast cancer susceptibility meet again
Nature Genetics (2010)
-
Cancer incidence in relatives of British Fanconi Anaemia patients
BMC Cancer (2008)
-
Hereditary breast cancer: new genetic developments, new therapeutic avenues
Human Genetics (2008)
-
FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway
The EMBO Journal (2007)