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More to Hi-C than meets the eye

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Diversification and specialization of high-throughput technologies demand assay-specific treatment of data for reliable interpretation. A new study shows that data generated using the Hi-C approach contain hidden features of interchromosomal DNA interactions, which are revealed through analysis with an integrated probabilistic model that corrects for multiple sources of bias in the data.

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Figure 1: Correcting Hi-C data for systematic biases and subsequent analyses suggest that DNase I hypersensitivity is most directly correlated with physical DNA interactions.

References

  1. Irizarry, R.A., Wu, Z. & Jaffee, H.A. Bioinformatics. 22, 789–794 (2006).

    Article  CAS  Google Scholar 

  2. Lieberman-Aiden, E. et al. Science 326, 289–293 (2009).

    Article  CAS  Google Scholar 

  3. Yaffe, E. & Tanay, A. Nat. Genet. 43, 1059–1065 (2011).

    Article  CAS  Google Scholar 

  4. Dekker, J. Nat. Methods 3, 17–21 (2006).

    Article  CAS  Google Scholar 

  5. Simonis, M., Kooren, J. & de Laat, W. Nat. Methods 4, 895–901 (2007).

    Article  CAS  Google Scholar 

  6. Hakim, O., Sung, M.H. & Hager, G.L. Curr. Opin. Cell Biol. 22, 305–313 (2010).

    Article  CAS  Google Scholar 

  7. Kocanova, S. et al. PLoS Genet. 6, e1000922 (2010).

    Article  Google Scholar 

  8. Hakim, O. et al. Genome Res. 21, 697–706 (2011).

    Article  CAS  Google Scholar 

  9. Hesselberth, J.R. et al. Nat. Methods 6, 283–289 (2009).

    Article  CAS  Google Scholar 

  10. John, S. et al. Nat. Genet. 43, 264–268 (2011).

    Article  CAS  Google Scholar 

  11. Biddie, S.C. et al. Mol. Cell 43, 145–155 (2011).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Myong-Hee Sung and Gordon L. Hager are at the Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.,

    Myong-Hee Sung & Gordon L Hager

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  1. Myong-Hee Sung
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  2. Gordon L Hager
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Correspondence to Gordon L Hager.

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The authors declare no competing financial interests.

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Sung, MH., Hager, G. More to Hi-C than meets the eye. Nat Genet 43, 1047–1048 (2011). https://doi.org/10.1038/ng.984

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