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Germline BAP1 mutations and tumor susceptibility

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Two new studies describe germline mutations in BAP1 in putatively dissimilar cancer-related syndromes. The spectrum of neoplasms associated with these germline mutations suggest that BAP1 has an important tumor suppressor function in multiple tissues.

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Authors and Affiliations

  1. Division of Cancer Epidemiology and Genetics, Alisa M. Goldstein is at the Genetic Epidemiology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.,

    Alisa M Goldstein

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  1. Alisa M Goldstein
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Correspondence to Alisa M Goldstein.

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Goldstein, A. Germline BAP1 mutations and tumor susceptibility. Nat Genet 43, 925–926 (2011). https://doi.org/10.1038/ng.956

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