Skip to main content

Advertisement

SpringerLink
Log in

GATA2 mutations lead to MDS and AML

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

Several new studies report mutations in the gene GATA2 in three different familial syndromes characterized by predisposition to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Before the onset of MDS and AML, patients with similar GATA2 mutations had distinct hematological abnormalities.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: GATA2 mutations.

References

  1. Owen, C., Barnett, M. & Fitzgibbon, J. Br. J. Haematol. 140, 123–132 (2008).

    Article  CAS  PubMed  Google Scholar 

  2. Hahn, C.N. et al. Nat. Genet. 43, 929–931 (2011).

    Article  Google Scholar 

  3. Ostergaard, P. et al. Nat. Genet. 43, 1012–1017 (2011).

    Article  Google Scholar 

  4. Mansour, S. et al. Am. J. Med. Genet. A. 152A, 2287–2296 (2010).

    Article  PubMed  Google Scholar 

  5. Hsu, A.P. et al. Blood published online, doi:10.1182/blood-2011-05-356352 (13 June 2011).

  6. Dickinson, R.E. et al. Blood published online, doi:10.1182/blood-2011-06-360313 (15 July 2011).

  7. Vinh, D.C. et al. Blood 115, 1519–1529 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Calvo, K.R. et al. Haematol. 96, 1221–1225 (2011).

    Article  Google Scholar 

  9. Bigley, V. et al. J. Exp. Med. 208, 227–234 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Rodrigues, N.P. et al. Blood 112, 4862–4873 (2008).

    Article  CAS  PubMed  Google Scholar 

  11. Zhang, S.J. et al. Proc. Natl. Acad. Sci. USA 105, 2076–2081 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Zhang, S.J., Shi, J.Y. & Li, J.Y. Leuk. Res. 33, 1141–1143 (2009).

    Article  CAS  PubMed  Google Scholar 

  13. Vicente, C., Conchillo, A., Garcia-Sanchez, M.A. & Odero, M.D. Crit. Rev. Oncol. Hematol. published online, doi:10.1016/jcritrevonc.2011.04.007 (24 May 2011).

  14. Wechsler, J. et al. Nat. Genet. 32, 148–152 (2002).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. R. Katherine Hyde and P. Paul Liu are in the Oncogenesis and Development Section at the National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.,

    R. Katherine Hyde & P. Paul Liu

Authors
  1. R. Katherine Hyde
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Paul Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. Paul Liu.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hyde, R., Liu, P. GATA2 mutations lead to MDS and AML. Nat Genet 43, 926–927 (2011). https://doi.org/10.1038/ng.949

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.949

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation