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Lyp breakdown and autoimmunity

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A new study shows that the PTPN22 coding variant associated with autoimmunity is a loss-of-function allele that causes the protein tyrosine phosphatase encoded by PTPN22 to undergo accelerated degradation, resulting in enhanced signaling in several immune cell types.

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Figure 1: Proposed mechanism for enhanced immune cell signaling in Pep619W knock-in mice.

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Authors and Affiliations

  1. Timothy W. Behrens is in the Division of Immunology, Tissue Growth & Repair, Biomarker Discovery and Human Genetics, Genentech, South San Francisco, California, USA.,

    Timothy W Behrens

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  1. Timothy W Behrens
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Correspondence to Timothy W Behrens.

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T.W.B. is a full-time employee of Genentech.

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Behrens, T. Lyp breakdown and autoimmunity. Nat Genet 43, 821–822 (2011). https://doi.org/10.1038/ng.914

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