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The long reach of noncoding RNAs

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Transcription of genomic loci containing protein-coding genes often yields not only cognate mRNAs but also assorted noncoding RNAs (ncRNAs), which typically map in the vicinity of transcription start sites. A new study shows that far from being random byproducts of gene expression, many long ncRNAs (lncRNAs) are synthesized in a coordinate fashion and control important cellular processes, such as survival in the face of DNA damage.

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Figure 1: Model of pro-survival effects of PANDA lncRNA during the DNA damage response.

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Acknowledgements

The authors are supported by the National Institutes of Health grant CA122334 (A.T.-T.) and Alex's Lemonade Stand Foundation Innovation (A.T.-T.) and Young Investigator (E.S.) awards.

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  1. Elena Sotillo and Andrei Thomas-Tikhonenko are in the Division of Cancer Pathobiology, Department of Pathology & Laboratory Medicine, The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, USA.,

    Elena Sotillo & Andrei Thomas-Tikhonenko

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  1. Elena Sotillo
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  2. Andrei Thomas-Tikhonenko
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Correspondence to Andrei Thomas-Tikhonenko.

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Sotillo, E., Thomas-Tikhonenko, A. The long reach of noncoding RNAs. Nat Genet 43, 616–617 (2011). https://doi.org/10.1038/ng.870

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