Skip to main content
SpringerLink
Log in

Mapping higher order structure of chromatin domains

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

Large-scale mapping of chromatin state and transcription factor binding have uncovered many broad chromatin domains along linear genomic DNA, but it is unclear how these functional domains are organized in three-dimensional nuclear space. A new study now shows that many domains exist as loops connected by CCTC-binding factor (CTCF), providing new insights into the higher-order structure of chromatin organization in the nucleus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Five distinct chromatin domains are found in association with CTCF in mouse embryonic stem cells.

References

  1. Misteli, T. Cell 128, 787–800 (2007).

    Article  CAS  Google Scholar 

  2. Zhou, V.W., Goren, A. & Bernstein, B.E. Nat. Rev. Genet. 12, 7–18 (2011).

    Article  Google Scholar 

  3. Guelen, L. et al. Nature 453, 948–951 (2008).

    Article  CAS  Google Scholar 

  4. Hawkins, R.D. et al. Cell Stem Cell 6, 479–491 (2010).

    Article  CAS  Google Scholar 

  5. Handoko, L. et al. Nat. Genet. 43, 630–638 (2011).

    Article  CAS  Google Scholar 

  6. Fullwood, M.J. et al. Nature 462, 58–64 (2009).

    Article  CAS  Google Scholar 

  7. Phillips, J.E. & Corces, V.G. Cell 137, 1194–1211 (2009).

    Article  Google Scholar 

  8. Bell, A.C., West, A.G. & Felsenfeld, G. Cell 98, 387–396 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Celso A. Espinoza and Bing Ren are at the Ludwig Institute for Cancer Research at the University of California, San Diego, La Jolla, California, USA.,

    Celso A Espinoza & Bing Ren

Authors
  1. Celso A Espinoza
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bing Ren
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bing Ren.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Espinoza, C., Ren, B. Mapping higher order structure of chromatin domains. Nat Genet 43, 615–616 (2011). https://doi.org/10.1038/ng.869

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.869

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation