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Interferon-alfa, interferon-λ and hepatitis C

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Three new studies report genetic variants near IL28B, which encodes interferon-λ3 (interleukin 28B), are associated with response to treatment of chronic hepatitis C virus infection with interferon-alfa/ribavirin combination therapy. This renews interest in how interferons suppress viremia and could lead to improved clinical decisions for chronic HCV infection treatment based on individual genotype.

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Figure 1: The interferon-λ proteins induce the JAK-STAT antiviral pathway by binding to different receptors than interferon-α and interferon-alfa.

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Authors and Affiliations

  1. Thomas R. O'Brien is at the Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.,

    Thomas R O'Brien

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  1. Thomas R O'Brien
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Correspondence to Thomas R O'Brien.

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O'Brien, T. Interferon-alfa, interferon-λ and hepatitis C. Nat Genet 41, 1048–1050 (2009). https://doi.org/10.1038/ng.453

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