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Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer

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ERG overexpression in prostate cancers promotes the development of widespread changes in gene expression and chromatin landscapes, leading to redistribution of key transcription factors in prostate cancers positive for the TMPRSS2-ERG fusion gene. The overexpression of ERG is further assisted by the development of a super-enhancer in the ERG locus.

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Figure 1: Nucleus of a T2E-positive prostate cancer cell.

Debbie Maizels/Springer Nature

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Authors and Affiliations

  1. the Cancer Science Institute of Singapore, National University of Singapore, Singapore

    Deepak Babu & Melissa J Fullwood

  2. the School of Biological Sciences, Nanyang Technological University, Singapore, and the Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore

    Melissa J Fullwood

Authors
  1. Deepak Babu
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  2. Melissa J Fullwood
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Corresponding author

Correspondence to Melissa J Fullwood.

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Competing interests

M.J.F. declares two patents on chromatin interaction technologies.

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Babu, D., Fullwood, M. Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer. Nat Genet 49, 1294–1295 (2017). https://doi.org/10.1038/ng.3944

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