Severe allergic disease is common, and few monogenic causes of atopy have been described. A new study that convincingly links severe atopic dermatitis to heterozygous CARD11 mutations with dominant-interfering activity serves as a timely reminder that clinicians should consider the possibility of an underlying monogenic immune disorder when caring for patients suffering from severe allergic disease.
References
Al-Herz, W. et al. Front. Immunol. 5, 162 (2014).
Lo, B. et al. Science 349, 436–440 (2015).
Bousfiha, A.A. et al. J. Clin. Immunol. 33, 1–7 (2013).
Ma, C.A. et al. Nat. Genet. 49, 1192–1201 (2017).
Turvey, S.E. et al. J. Allergy Clin. Immunol. 134, 276–284 (2014).
Greil, J. et al. J. Allergy Clin. Immunol. 131, 1376–1383.e3 (2013).
Stepensky, P. et al. J. Allergy Clin. Immunol. 131, 477–485.e1 (2013).
Snow, A.L. et al. J. Exp. Med. 209, 2247–2261 (2012).
Buchbinder, D. et al. J. Allergy Clin. Immunol. 136, 819–821.e1 (2015).
Jun, J.E. et al. Immunity 18, 751–762 (2003).
Tarailo-Graovac, M. et al. N. Engl. J. Med. 374, 2246–2255 (2016).
Holland, S.M. et al. N. Engl. J. Med. 357, 1608–1619 (2007).
Engelhardt, K.R. et al. J. Allergy Clin. Immunol. 124, 1289–1302.e4 (2009).
Sassi, A. et al. J. Allergy Clin. Immunol. 133, 1410–1419.e13 (2014).
Zhang, Y. et al. J. Allergy Clin. Immunol. 133, 1400–1409.e5 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Biggs, C., Lu, H. & Turvey, S. Monogenic immune disorders and severe atopic disease. Nat Genet 49, 1162–1163 (2017). https://doi.org/10.1038/ng.3925
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.3925
- Springer Nature America, Inc.