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The osteoarthritis and height GDF5 locus yields its secrets

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A new study reports molecular characterization of the GDF5 locus, which is associated with osteoarthritis risk and adult height in humans. This study provides evidence of positive selection for short stature at GDF5 in modern humans, as well as in archaic Neandertals and Denisovans.

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Authors and Affiliations

  1. Montreal Heart Institute and the Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada

    Guillaume Lettre

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  1. Guillaume Lettre
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Correspondence to Guillaume Lettre.

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Lettre, G. The osteoarthritis and height GDF5 locus yields its secrets. Nat Genet 49, 1165–1166 (2017). https://doi.org/10.1038/ng.3924

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