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Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures

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Acknowledgements

A.S. is supported by the Chris Rokos Fellowship in Evolution and Cancer. B.W. is supported by the Geoffrey W. Lewis Post-Doctoral Training Fellowship. This work was supported by the Wellcome Trust (105104/Z/14/Z). C.P.B. acknowledges funding from the Wellcome Trust through a Research Career Developmental Fellowship (097319/Z/11/Z). This work was supported by a Cancer Research UK Career Developmental Award to T.A.G. M.J.W. is supported by a UK Medical Research Council student fellowship.

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Authors and Affiliations

  1. Evolution and Cancer Laboratory, Barts Cancer Institute, Queen Marry University of London, London, UK

    Marc J Williams & Trevor A Graham

  2. Department of Cell and Developmental Biology, University College London, London, UK

    Marc J Williams & Chris P Barnes

  3. Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London, UK

    Marc J Williams

  4. Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK

    Benjamin Werner & Andrea Sottoriva

  5. Department of Genetics, Evolution and Environment, University College London, London, UK

    Chris P Barnes

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  1. Marc J Williams
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  2. Benjamin Werner
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  3. Chris P Barnes
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  4. Trevor A Graham
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  5. Andrea Sottoriva
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Corresponding authors

Correspondence to Trevor A Graham or Andrea Sottoriva.

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Williams, M., Werner, B., Barnes, C. et al. Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures. Nat Genet 49, 1289–1291 (2017). https://doi.org/10.1038/ng.3877

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