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Untangling the genetics from the epigenetics in pancreatic cancer metastasis

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Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.

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Figure 1: An epigenomic reprogramming model of pancreatic cancer metastasis.

Marina Corral Spence/Springer Nature

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Authors and Affiliations

  1. Christopher R. Vakoc and David A. Tuveson are at Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.,

    Christopher R Vakoc & David A Tuveson

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  1. Christopher R Vakoc
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  2. David A Tuveson
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Correspondence to Christopher R Vakoc or David A Tuveson.

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The authors declare no competing financial interests.

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Vakoc, C., Tuveson, D. Untangling the genetics from the epigenetics in pancreatic cancer metastasis. Nat Genet 49, 323–324 (2017). https://doi.org/10.1038/ng.3798

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