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A multitrait GWAS sheds light on insulin resistance

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A genome-wide study of fasting insulin, HDL cholesterol and triglycerides, designed to depict insulin resistance, identified 53 independent loci associated with a limited capacity to store fat in a healthy way. The increased power of this multitrait approach provides insights into an otherwise difficult-to-grasp phenotype.

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Figure 1: Relationship between genetic effects on hip circumference and type 2 diabetes risk.

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Authors and Affiliations

  1. Iris M. Heid and Thomas W. Winkler are in the Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.,

    Iris M Heid & Thomas W Winkler

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  1. Iris M Heid
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  2. Thomas W Winkler
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Correspondence to Iris M Heid.

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The authors declare no competing financial interests.

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Heid, I., Winkler, T. A multitrait GWAS sheds light on insulin resistance. Nat Genet 49, 7–8 (2017). https://doi.org/10.1038/ng.3758

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