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A saltationist theory of cancer evolution

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A new study based on single-nucleus sequencing reports that triple-negative breast cancers acquire copy number aberrations in short punctuated bursts in the earliest stages of tumor evolution, rather than continuously and gradually, challenging prevailing models of tumor evolution.

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Figure 1: Two models of tumor evolution.

References

  1. Nowell, P.C. Science 194, 23–28 (1976).

    Article  CAS  Google Scholar 

  2. Gao, R. et al. Nat. Genet. 48, 1119–1130 (2016).

    Article  CAS  Google Scholar 

  3. Sottoriva, A. et al. Nat. Genet. 47, 209–216 (2015).

    Article  CAS  Google Scholar 

  4. Ling, S. et al. Proc. Natl. Acad. Sci. USA 112, E6496–E6505 (2015).

    Article  CAS  Google Scholar 

  5. Williams, M.J., Werner, B., Barnes, C.P., Graham, T.A. & Sottoriva, A. Nat. Genet. 48, 238–244 (2016).

    Article  CAS  Google Scholar 

  6. Hicks, J. et al. Genome Res. 16, 1465–1479 (2006).

    Article  CAS  Google Scholar 

  7. Baca, S.C. et al. Cell 153, 666–677 (2013).

    Article  CAS  Google Scholar 

  8. Stephens, P.J. et al. Cell 144, 27–40 (2011).

    Article  CAS  Google Scholar 

  9. Shah, S.P. et al. Nature 486, 395–399 (2012).

    Article  CAS  Google Scholar 

  10. Zhang, C.-Z. et al. Nature 522, 179–184 (2015).

    Article  CAS  Google Scholar 

  11. Garsed, D.W. et al. Cancer Cell 26, 653–667 (2014).

    Article  CAS  Google Scholar 

  12. Eldredge, N. & Gould, S.J. in Models in Paleobiology (ed. Schopf, T.) 82–115 (Freeman, Cooper & Co, 1972).

    Google Scholar 

  13. Goldschmidt, R. The Material Basis of Evolution (Yale University Press, 1940).

    Google Scholar 

  14. Gould, S.J. Nat. Hist. 86, 22–30 (1976).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Florian Markowetz is at the University of Cambridge, Cancer Research UK Cambridge Institute, Cambridge, UK.,

    Florian Markowetz

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  1. Florian Markowetz
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Correspondence to Florian Markowetz.

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Markowetz, F. A saltationist theory of cancer evolution. Nat Genet 48, 1102–1103 (2016). https://doi.org/10.1038/ng.3687

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