A common ancestor of the modern codfish acquired a set of mutations that eliminated a major arm of the adaptive immune system—the MHC II pathway of antigen presentation to CD4+ T cells. Subsequent to this event, there was a radiation of these fish in which the number and diversity of MHC I genes increased in species-specific ways.
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Parham, P. How the codfish changed its immune system. Nat Genet 48, 1103–1104 (2016). https://doi.org/10.1038/ng.3684
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DOI: https://doi.org/10.1038/ng.3684
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