Skip to main content
SpringerLink
Log in

A plethora of pleiotropy across complex traits

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

A new analysis has identified hundreds of loci that are associated with multiple traits or diseases by comparing genome-wide association study (GWAS) data for 42 complex traits. The study uses the power of GWAS to provide evidence of pairs of traits with a likely causal relationship.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Inferring causal relationship between traits based on asymmetry in GWAS results.

References

  1. Lynch, M. & Walsh, B. Genetics and Analysis of Quantitative Traits (Sinauer Associates, Sunderland, Massachusetts, USA, 1998).

    Google Scholar 

  2. Lee, S.H. et al. Nat. Genet. 45, 984–994 (2013).

    Article  CAS  Google Scholar 

  3. Bulik-Sullivan, B. et al. Nat. Genet. 47, 1236–1241 (2015).

    Article  CAS  Google Scholar 

  4. Pickrell, J.K. et al. Nat. Genet. 48, 709–717 (2016).

    Article  CAS  Google Scholar 

  5. Williams, G.C. Evolution 11, 398–411 (1957).

    Article  Google Scholar 

  6. White, J.K. et al. Cell 154, 452–464 (2013).

    Article  CAS  Google Scholar 

  7. Solovieff, N., Cotsapas, C., Lee, P.H., Purcell, S.M. & Smoller, J.W. Nat. Rev. Genet. 14, 483–495 (2013).

    Article  CAS  Google Scholar 

  8. GTEx Consortium. Nat. Genet. 45, 580–585 (2013).

  9. Zhu, Z. et al. Nat. Genet. 48, 481–487 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Peter M. Visscher and Jian Yang are at the Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.,

    Peter M Visscher & Jian Yang

Authors
  1. Peter M Visscher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jian Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Peter M Visscher or Jian Yang.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Visscher, P., Yang, J. A plethora of pleiotropy across complex traits. Nat Genet 48, 707–708 (2016). https://doi.org/10.1038/ng.3604

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3604

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation