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The requirement of iron transport for lymphocyte function

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Iron is essential in multiple cellular processes and is especially critical for cellular respiration and division. A new study identified a mutation affecting the iron import receptor TfR1 as the cause of a human primary immunodeficiency, illuminating the importance of iron in immune cell function.

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Figure 1: Patients with a homozygous mutation encoding a p.Tyr20His substitution in TfR1 have impaired receptor endocytosis and iron import into cells.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. and in the Division of Translational Medicine, Bernice Lo is in the Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA, Sidra Medical and Research Center, Doha, Qatar.,

    Bernice Lo

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  1. Bernice Lo
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Correspondence to Bernice Lo.

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Lo, B. The requirement of iron transport for lymphocyte function. Nat Genet 48, 10–11 (2016). https://doi.org/10.1038/ng.3478

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