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Diabetes in the post-GWAS era

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Large sample sizes, high-resolution arrays and comprehensive imputation are pushing genetic fine-mapping of complex trait loci to its limits without, in most cases, pinpointing a unique variant-gene combination. Superimposing these results on sophisticated maps of functional chromatin elements promises to break this logjam, as a new study of type 2 diabetes compellingly demonstrates.

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Figure 1: Proposed mechanism for the contribution of variation in MTNR1B to type 2 diabetes risk.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Child Health and Human Development Program and Department of Pediatrics, Constantin Polychronakos and Maha Alriyami are at The Endocrine Genetics Laboratory, McGill University Health Centre Research Institute, Montreal, Quebec, Canada.,

    Constantin Polychronakos & Maha Alriyami

Authors
  1. Constantin Polychronakos
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  2. Maha Alriyami
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Correspondence to Constantin Polychronakos.

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The authors declare no competing financial interests.

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Polychronakos, C., Alriyami, M. Diabetes in the post-GWAS era. Nat Genet 47, 1373–1374 (2015). https://doi.org/10.1038/ng.3453

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