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Linking germline and somatic variation in Ewing sarcoma

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The identification of gene-regulatory polymorphisms that influence cancer susceptibility can identify key oncogenic pathways. A new study links a germline variant to Ewing sarcoma disease susceptibility and EWSR1-FLI1–mediated gene activation.

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Figure 1: Inherited variation on chromosome 10 near EGR2 influences Ewing sarcoma susceptibility by altering a binding site for EWSR1-FLI1.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Nicholas C. Gomez and Ian J. Davis are in the Department of Genetics and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.,

    Nicholas C Gomez & Ian J Davis

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  1. Nicholas C Gomez
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  2. Ian J Davis
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Correspondence to Ian J Davis.

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The authors declare no competing financial interests.

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Gomez, N., Davis, I. Linking germline and somatic variation in Ewing sarcoma. Nat Genet 47, 964–965 (2015). https://doi.org/10.1038/ng.3387

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